The active ingredient in TesoLean is Tesofensine, and this is categorised as a pre-synaptic reuptake inhibitor. When neuro chemicals (serotonin, dopamine and noradrenaline) are prevented from being reabsorbed by the central nervous system, the body responds by feeling less hungry. Patients therefore are more inclined to have smaller meals and are less likely to snack. Tesofensine also appears to affect the pleasure sensation of food consumption by modulating the action of dopamine on a particular sector of the brain.

In a double-bind trial with 203 people (with half given a placebo) those taking the placebo had lost 2.0% of body weight while those taking the medication with the active ingredient had experienced far more successful results. For those taking the lowest dose of 0.25 mg, average weight loss was 6.5%, those taking the medium dose of 0.5% lost 11.2% and those taking the highest dose of 1 mg lost 12.6%. In the two highest dose groups, the treatment led to a 4 point drop in BMI in a period of 24 weeks.

TesoLean is a promising option to those who would like to lose weight. But bare in mind that you still need to adopt a healthy lifestyle that includes a balanced diet and regular exercise is crucial for achieving sustainable weight loss.